2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W025812
    Boc-NH-PEG2-CH2CH2COOH 1365655-91-9
    Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG2-CH2CH2COOH
  • HY-140456
    Azido-PEG12-acid 2152679-71-3 99.10%
    Azido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG12-acid
  • HY-W004710
    NH2-C5-NH-Boc 51644-96-3 99.88%
    NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-C5-NH-Boc
  • HY-W021787
    NH2-PEG4-CH2CH2COOH 663921-15-1 99.88%
    NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG4-CH2CH2COOH
  • HY-116006
    Bis-PEG5-acid 439114-13-3
    Bis-PEG5-acid (PROTAC Linker 36) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. Bis-PEG5-acid (PROTAC Linker 36) can be used in the synthesis of the CP5V. CP5V is a PROTAC, and specifically degrades Cdc20.
    Bis-PEG5-acid
  • HY-43721
    N-Boc-4-pentyne-1-amine 151978-50-6 98.25%
    N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122). N-Boc-4-pentyne-1-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-Boc-4-pentyne-1-amine
  • HY-W096120
    Azide-PEG3-Desthiobiotin 1426828-06-9
    Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Desthiobiotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG3-Desthiobiotin
  • HY-140182
    Amino-PEG24-acid 2563873-76-5 ≥98.0%
    Amino-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG24-acid
  • HY-140752
    DOTA-PEG5-azide ≥98.0%
    DOTA-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    DOTA-PEG5-azide
  • HY-140797
    Azido-PEG2-alcohol 139115-90-5 99.49%
    Azido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-alcohol
  • HY-W019798
    NH2-PEG8-acid 756526-04-2 ≥98.0%
    NH2-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG8-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG8-acid
  • HY-140216
    Azido-PEG8-amine 857891-82-8
    Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-amine
  • HY-40141
    1-Boc-azetidine-3-carboxylic acid 142253-55-2 ≥98.0%
    1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
    1-Boc-azetidine-3-carboxylic acid
  • HY-140033
    Propargyl-PEG3-amine 932741-19-0 ≥98.0%
    Propargyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-amine
  • HY-140480
    Acid-PEG2-C2-Boc 2086688-99-3 ≥98.0%
    Acid-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG2-C2-Boc
  • HY-140459
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9 ≥98.0%
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
  • HY-W018464
    N-Boc-serinol 125414-41-7
    N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-serinol
  • HY-43614
    Propynol Ethoxylate 3973-18-0
    Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propynol Ethoxylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propynol Ethoxylate
  • HY-140273
    DBCO-PEG8-NHS ester 2553412-88-5 98.34%
    DBCO-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG8-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG8-NHS ester
  • HY-130898
    BM-PEG3 86099-06-1 ≥98.0%
    BM-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    BM-PEG3
PROTAC Linkers Isoform Comparison

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